| abstract |
PROBLEM TO BE SOLVED: To use a special apparatus for an aqueous solution of liposomes that holds an active ingredient that is effective against skin but is unstable and cannot be formulated at a high concentration because of irritation, etc. A skin cosmetic base and a skin cosmetic excellent in stability over time are provided. An active ingredient for skin is added to an oil phase and / or an aqueous phase, phospholipids forming a liposome skeleton and an oil-soluble component serving as a membrane stabilizer are dissolved by heating to prepare an oil phase, A high-concentration saccharide aqueous solution is kept above the liposome membrane phase transition temperature and added to the oil phase while stirring little by little to form a lamellar liquid crystal, and the aqueous phase is stirred and added above the liposome membrane phase transition temperature. A method for producing a skin cosmetic base, comprising preparing an aqueous liposome solution that retains an active ingredient against lipase and then freeze-drying the aqueous liposome solution. [Selection figure] None |