| abstract |
PROBLEM TO BE SOLVED: To provide an amino acid sequence of human-derived PGIS and provide DNA encoding the human-derived PGIS and the PGIS. SOLUTION: DNA comprising a DNA having a base sequence encoding the amino acid sequence of human prostacyclin synthase (PGIS) substantially represented by SEQ ID NO: 12, a vector containing the DNA, and transformed with the vector A host cell and a method for producing human-derived PGIS by culturing the host cell in a medium. A polypeptide substantially having the amino acid sequence of human-derived PGIS represented by SEQ ID NO: 12, and an antibody reactive to the human-derived PGIS. A pharmaceutical composition comprising the DNA or a vector containing the DNA. A method for promoting PGI 2 production, which comprises introducing the DNA or a vector containing the DNA into a living body, or a method for treating a disease caused by a decrease in PGI 2 production. [Selection figure] None |