| abstract |
To produce a drug that inhibits the activity of luteinizing hormone-releasing hormone (LHRH) as a therapeutic agent for diseases in which sex steroids have an important role. As potent LHRH antagonists, acyl groups (furo-2-yl, isonicotinyl, nicotinyl, 2-quinolinecarbonyl, 3-quinolinecarbonyl, 4-quinolinecarbonyl, shikimyl, dihydroshikimyl, tetrahydroflu-2-yl oil Decapeptides and undecapeptides were found that were substituted on the N-terminal nitrogen atom. [Effect] It is effective in suppressing sex hormone levels in mammals. [Selection figure] None |