| abstract |
To provide a 2-aminoquinazoline derivative having an adenosine A 2A receptor antagonistic action or the like or a pharmacologically acceptable salt thereof. SOLUTION: Formula (I) [Chemical 9] [Wherein R 1 and R 2 are the same or different and each represents a hydrogen atom, a substituted or unsubstituted lower alkyl, a substituted or unsubstituted aryl, a substituted or unsubstituted aromatic heterocyclic group, a substituted or unsubstituted fat A cyclic heterocyclic group, -C (= Y) R 5 (wherein Y represents an oxygen atom or a sulfur atom, R 5 represents a substituted or unsubstituted lower alkyl, a substituted or unsubstituted lower alkoxy, etc.) Or R 1 and R 2 together with the adjacent nitrogen atom form a substituted or unsubstituted aromatic heterocyclic group, etc. R 3 represents substituted or unsubstituted aryl, etc. R 4 represents a hydrogen atom or substituted or unsubstituted lower alkyl], or a pharmacologically acceptable salt thereof. [Selection figure] None |