| abstract |
The present invention provides a composition for increasing cholesterol efflux and increasing HDL using an ATP-binding cassette transporter ABC1. A novel ABC1 polypeptide and a nucleic acid molecule encoding the same, a recombinant vector, a host cell, and a composition comprising the ABC1 polynucleotide, and a method for producing the ABC1 polypeptide, specifically to the ABC1 polypeptide Antibodies that bind, methods of increasing cholesterol efflux and methods of increasing ABC1 expression and activity, methods of identifying compounds that modulate ABC1 expression, and methods of detecting comparative levels of ABC1 polypeptides and polynucleotides in mammalian subjects , Kits and compositions suitable for screening compounds to measure the ABC1 expression modulating activity of the compounds, and kits and compositions suitable for determining whether a compound modulates ABC1-dependent cholesterol efflux Stuff [Selection figure] None |