| abstract |
A halogen-lithium exchange reaction that is industrially suitable for synthesizing compounds useful in the chemical industry, particularly in the fields of pharmaceuticals, agricultural chemicals, liquid crystals, electrophotography, dyes, etc., at low cost without using ultra-low temperature cooling equipment In addition, the present invention provides a production method which is safe and can be performed safely and has extremely high practical utility. A halogen compound and an organolithium reagent are reacted in at least one continuous reactor to produce a lithium compound represented by the formula (I), and if necessary, reacted with an electrophilic compound. To produce a compound represented by the formula (II) (wherein the ring represented by A represents an aromatic ring, a saturated ring, a partially saturated ring or a heterocyclic ring, and Y represents an electrophilic group). [Chemical 1] [Selection figure] None |