| abstract |
PROBLEM TO BE SOLVED: To provide a gastrointestinal mucoadhesive microsphere which is excellent in adhesion and retention in the gastrointestinal mucosa and has high persistence of contained medicinal ingredients in the gastrointestinal tract. SOLUTION: A microsphere comprising an anionic hydrophilic polymer powder, a cationic hydrophilic polymer powder, a hydrophobic base, and a medicinal component, wherein the anionic hydrophilic polymer is in particular a carboxyl. A microsphere comprising a polysaccharide or a synthetic polymer containing a group and / or a sulfate group, wherein the cationic hydrophilic polymer is a cationic polysaccharide, a polypeptide or a synthetic polymer. [Selection figure] None |