| abstract |
[PROBLEMS] To provide a method for screening a substance causing a decrease in the activity of endothelial lipase, and to treat or prevent one or more diseases selected from hyperlipidemia, hypoHDLemia, arteriosclerosis and hyperglycemia. One or more diseases selected from test methods, HDL cholesterol, phospholipids, angiopoietin-related protein 3, angiopoietin-related protein 4 quantification method, hyperlipidemia, hypoHDLemia, arteriosclerosis and hyperglycemia A therapeutic or prophylactic pharmaceutical composition is provided. A screening method for a substance that causes a decrease in activity of endothelial lipase (hereinafter referred to as “EL”), including the following steps (1) to (2): (1) a test substance; A step of contacting the angiopoietin-related protein 3 or the angiopoietin-related protein 4 and endocerial lipase and its substrate and measuring the activity of endothelial lipase; (2) a step of selecting a substance having reduced EL activity. [Selection figure] None |