| abstract |
PROBLEM TO BE SOLVED: To provide a flavonoid derivative having various functions possessed by flavonoids and having high inhibitory activity against matrix metalloprotease, urokinase, hyaluronidase and elastase. SOLUTION: A polymer inhibitor having an activity of inhibiting the activity of matrix metalloprotease, urokinase, hyaluronidase and elastase by oxidative polymerization of epigallocatechin gallate. One or more selected from the group consisting of osteoarthritis, periodontal disease, HIV infection, diabetic complications, aneurysm, cirrhosis, ulceration, bone disease, pulmonary fibrosis, dermatitis, skin allergy and skin aging Used as a remedy or preventive for symptoms or phenomena. [Selection figure] None |