| abstract |
The present invention suppresses bone resorption in mammals while minimizing the occurrence or possibility of adverse effects on the gastrointestinal tract. An effective dose of a unit dose according to a continuous schedule having a dosing interval selected from the group consisting of once weekly dosing, twice weekly dosing, biweekly dosing and twice monthly dosing. The above-mentioned problems are solved by orally administering bisphosphonate and by a pharmaceutical composition and kit therefor. [Selection figure] None |