| abstract |
A method and means for preventing and treating malaria, schistosomiasis and cancer. A method for treating and preventing malaria, schistosomiasis and cancer using spiro or dispiro 1,2,4-trioxolanes is provided. Preferred 1,2,4-trioxolanes are those containing a spiroadamantane group on one side of the trioxolane group and a spirocyclohexyl ring on the other side of the trioxolane group. In this case, the 4-position of the spirocyclohexyl ring is preferably substituted. Compared to artemisinin semi-synthetic derivatives, the compounds of the present invention are structurally simple, easy to synthesize, non-toxic and have great potency against malaria parasites. |