| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a1d60a93d4b13542095fea713d7770fd |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D205-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F7-1804
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F7-1892 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D205-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F7-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07B61-00 |
| filingDate |
2004-11-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f2f9961b6c9f29e7fee891db2549c116
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8f44ffdf62fefaa3aa00251c3480d20e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fb1dc8bf7475153797d8c9628c430995
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5ceecbfb9c7bba01ed5f6143cf255313
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4b391da45ef7d56a929d07f82b3a82af
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cb86864473a238f6de6641a71af3c118 |
| publicationDate |
2005-03-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
JP-2005053931-A |
| titleOfInvention |
Synthesis process of azetidinone |
| abstract |
PROBLEM TO BE SOLVED: To provide a simple high-yield improved process for producing a hypocholesterolemic agent azetidinone having the formula I. The present invention provides a process for preparing the hypocholesterolemic compound (I), which process comprises the following steps: (a) reacting p-fluorobenzoylbutyric acid with pivaloyl chloride. Acylating the product with a chiral auxiliary to give a ketone of formula (IV); (b) reducing the ketone of formula (IV) to an alcohol in the presence of a chiral catalyst; (c) Reacting the chiral alcohol, imine and silyl protecting agent of step (b) and then condensing the protected compound to give a β- (substituted amino) amide of formula (VII); (d) formula (VII) Cyclizing the β- (substituted amino) amide of silylation with a silylating agent and a fluoride ion catalyst to obtain a protected lactam of formula (VIII). Intermediates of formula (VII and VIII) are also claimed. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2008545700-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2008542205-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2008540557-A |
| priorityDate |
1998-12-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |