| abstract |
Pharmaceutical composite compositions comprising tetrahydroindolones and derivatives thereof linked to an arylpiperazine are disclosed. Specifically, disclosed are composite compositions that are useful in treating antipsychotic disorders. The composite composition disclosed herein effectively ameliorates symptoms and treats mental disorders without causing cognitive decline. Generally, the complex compound is comprised of two moieties, moieties A and B, wherein the tetrahydroindolone comprises moieties A linked to moiety B through a linker L, wherein B is an arylpiperazinyl moiety. is there. The composite compound provides antipsychotic activity by interacting with GABA, seratonin and dopamine receptors. Complex molecules with combined activity provide for treating psychiatric and neurological disorders without cognitive impairment. |