| abstract |
The present invention has the formula: Embedded image Wherein, in particular, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 and R 8 are hydrogen. T is oxygen, sulfur or NR 11 where R 11 is hydrogen or lower alkyl. V is -N <, -CH <or -N-CH <. X 1 is hydrogen, optionally substituted lower alkyl, optionally substituted cycloalkyl, optionally substituted aryl, or optionally substituted heteroaryl. X 2 is an optionally substituted aryl or an optionally substituted heteroaryl. Y is an optionally substituted monocyclic heteroarylenyl. And Z 1 and Z 2 are independently an optionally substituted alkylene having 1 to 4 carbon atoms]. The invention also relates to various disease states, especially cardiovascular diseases (eg, atrial arrhythmias, ventricular arrhythmias, intermittent rhythms, prinzmetal (abnormal) angina, stable angina, unstable angina, exercise-induced angina, congestion) Compounds useful for the treatment of congenital heart failure, and myocardial infarction). The present invention further provides compounds useful for treating diabetes and increasing plasma HDL levels in mammals. |