| abstract |
The present invention relates to compositions and methods for treating tumor cells and / or malignant cells and / or cancerous cells. The present invention relates to nucleic acids encoding cytokines (eg, interleukins or interferons), or suicide genes (eg, thymidine kinase), or other biological proteins (eg, heat shock protein gp96), or endostatin or angiostatin And wherein the VSV vector exhibits higher oncolytic activity on tumor and / or malignant and / or cancerous cells than a wild-type VSV vector. The present invention also provides such vectors, host cells, expression systems, and compositions containing such VSV vectors, and methods of making viral particles containing such VSV vectors. |