| abstract |
The present invention relates to nucleic acids encoding G-protein coupled receptors (GPCRs) and PGCRs predominantly expressed in the brain and placenta, referred to herein as hCAR protein and hCAR gene (for the human costimulatory receptor), respectively. Based on molecule identification. Based on this identification, the present invention provides (1) an isolated hCAR protein; (2) an isolated nucleic acid molecule encoding the hCAR protein; (3) an antibody that selectively binds to the hCAR protein; (4) an hCAR protein and gene. (5) a method for identifying cells and tissues that express the hCAR protein / gene; (6) a method for identifying reagents and cytoplasmic compounds that bind to the hCAR protein; (7) a method for identifying the hCAR gene. Methods for identifying a reagent that modulates expression; and (8) methods for modulating hCAR protein activity in a cell or organ are provided. |