http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2004536093-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D307-87 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D- http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C253-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-343 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07B57-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D307-87 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D307-93 |
| filingDate | 2002-06-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2004-12-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-2004536093-A |
| titleOfInvention | Process for producing racemic citalopram and / or S- or R-citalopram by separating a mixture of R- and S-citalopram |
| abstract | The present invention relates to the separation of a mixture of R- and S-citalopram containing one of the enantiomers in a proportion greater than 50% into a fraction consisting of racemic citalopram and / or a fraction of S-citalopram or R-citalopram. A process for producing R- or S-citalopram as a racemic citalopram free base or acid addition salt thereof and / or a free base or acid addition salt thereof, comprising i) citalopram as a free base or acid addition thereof Ii) separating the resulting precipitate from the mother liquor, wherein ia) if the precipitate is crystalline, it may be recrystallized once or more than once to racemic citalopram And then optionally converted to its acid addition salt, iib) the precipitate is amorphous In some cases, steps i) and ii) are repeated until a crystalline precipitate is obtained, and the resulting crystalline precipitate is recrystallized once or more to produce racemic citalopram, then To the acid addition salt thereof, iii) optionally subjecting the mother liquor to further purification and isolating S-citalopram or R-citalopram from the mother liquor, then optionally to its acid addition salt It relates to the above method characterized in that it is converted. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2009179634-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7834201-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2010150270-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7560576-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2012072168-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7723533-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2007524678-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2009179635-A |
| priorityDate | 2001-06-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 60.