| abstract |
[Object] To provide a novel crystalline form of an acid addition salt of amlodipine, which has low toxicity and satisfies the physicochemical conditions of a pharmaceutically acceptable salt. Amlodipine is treated with (1S)-(+)-10-camphorsulfonic acid, (1R)-(-)-10- and camphorsulfonic acid, or (±) -10-camphorsulfonic acid. The reaction produces a novel amlodipine camphorsulfonate of Formula 1 with excellent solubility, stability, non-hygroscopicity and tablet adhesion. Embedded image |