| abstract |
The disclosed invention relates to the use of nucleosides of general formulas (I)-(XXIII) or pharmaceutically acceptable salts or prodrugs thereof, in the flaviviridae family (including BVDV and HCV), in animals, particularly hosts, including humans, Compositions and methods for treating orthomyxoviridae (including influenza A and B) or paramyxoviridae (including RSV) viral infections, or conditions associated with abnormal cell proliferation. The present invention also provides an effective method for quantifying viral load in a host, particularly BVDV, HCV or West Nile virus, using real-time polymerase chain reaction ("TR-PCR"). Further, the present invention discloses probe molecules that can fluoresce in proportion to the amount of virus present in the sample. |