| abstract |
The present invention is in the field of biotechnology or genetic engineering. Specifically, the invention relates to the field of gene expression. More specifically, the present invention relates to novel substitution mutant reporters and their use in nuclear receptor-based inducible gene expression systems and gene therapy, large-scale production of proteins and antibodies, cell-based high throughput It relates to methods for modulating gene expression in host cells for applications such as screening assays, functional genomics and modulation of properties in transgenic organisms. |