| abstract |
A transdermally deliverable pharmaceutical composition comprises at least one cyclooxygenase-2 (COX-2) selective inhibitor or prodrug thereof solubilized in a pharmaceutically acceptable carrier containing a low molecular weight monohydric alcohol. Contains, the skin permeability of the therapeutic substance is at least equal to that obtained with a reference solution of the therapeutic substance in a 70% aqueous ethanol solution. A method for targeted delivery of a COX-2 selective inhibitor to a site of pain and / or inflammation in a subject comprises administering the composition to the skin of the subject, preferably on or at the site of pain and / or inflammation. Local administration to adjacent locations. How COX-2 performs the systemic treatment of a subject having a disorder mediated, their composition, preferably by contacting the composition to about 400 cm 2 or less of the area of the skin of a subject, transdermal administration Including doing. |