| abstract |
The present invention provides a compound of formula (I): Embedded image Wherein X 1 is Wherein R 1 , R 2 and R 10 are independently hydrogen or a suitable substituent; R 11 and R 12 are independently hydrogen or a suitable substituent; R is unsaturated be a 5-6 membered heteromonocyclic group; a is a direct bond or -NH-; X 2 is a single ring arylene, unsaturated 5-6-membered heteromonocyclic group or cycloalkenylene; Y is ethylene, trimethylene And a divalent residue selected from vinylene (in the group, CH 2 may be substituted with NH or O, and CH may be substituted with N); Z is-(CH 2 ) n- , -CO- (CH 2) m - , - CH = CH- or -CO-NH- (wherein, n is 1, 2 or 3, m is 1 or 2) it is. Or a salt thereof. The compounds of the present invention inhibit the secretion of apolipoprotein B (apoB) and are useful as medicaments for the prevention and treatment of diseases or conditions caused by increased circulating levels of apoB. |