| abstract |
The present invention is a method for enhancing the in vivo delivery of a chimeric oligonucleotide, including, for example, DNA / 2'OMeRNA, into a plant, animal, or human cell, comprising: Topically injecting or injecting into the tissue containing or adjacent to the tissue, and then, or alternatively, or simultaneously, transporting the chimeric oligonucleotide into the cells by iontophoresis. And gene therapy comprising iontophoretic transport of chimeric oligonucleotide DNA / 2'OMeRNA. The present invention relates to a specific chimeric oligonucleotide DNA / 2′OMeRNA capable of inducing or suppressing the expression of a specific gene involved in eye function by inducing or reversing a mutation in the specific gene, and an eye disease. It also relates to their use as therapeutic compositions for preventing or treating. |