| abstract |
The present invention relates to newly discovered polynucleotides encoding proteins involved in the cell signaling cascade (designated RET16), cloned, isolated and identified from TNF-alpha stimulated human microvascular endothelial cells, and mice. And the rat RET16 ortholog. Also described are RET16 polypeptide sequences, expression vectors, host cells, agonists, antagonists, antisense molecules, and antibodies related to the polynucleotides and / or polypeptides of the invention. Methods for screening modulators, especially inhibitors, of the human RET16 protein and the use of RET16 polynucleotides and polypeptides for therapeutic and diagnostic agents are described. |