abstract |
Compounds of formula (I), and pharmaceutically acceptable salts, solvates and hydrolysable esters thereof. Embedded image [Where, R 1 and R 2 are independently H or C 1-3 alkyl, or R 1 and R 2 attached to the same carbon atom together with the carbon atom to which they are attached are 3- May form a 5-membered cycloalkyl ring; X 1 represents O or S; R 3, R 4, R 8 and R 9 each independently represent H, halogen, -CH 3 or -OCH 3; R 5 represents H or C 1-6 alkyl, or R 4 and R 5 together form a 3- to 6-membered cycloalkyl ring; X 2 represents NH, NCH 3 or O; One of Y and Z is N and the other is O or S; R 6 represents phenyl or pyridyl (where N is located at the 2- or 3-position); and one or more halogen, CF 3 , C 1-6 linear or branched alkyl (halogen May be substituted (where R 6 is pyridyl, N is unsubstituted); R 7 is C 1-6 alkyl (optionally substituted with one or more halogens), —C 0-6 alkyl-5-membered heteroaryl, C 0-6 alkyl- (O) n -phenyl (in this case, , N is 0 or 1 (where R 1 and R 2 are methyl, R 8 and R 9 are H, and R 5 is H, R 7 is not CH 3 or CF 3 )] . |