| abstract |
The invention includes a transcriptional unit encoding a signal sequence of one flavivirus and an immunogenic flavivirus antigen of a second flavivirus, or a chimeric immunogenic flavivirus antigen comprising sequences from multiple flaviviruses. , Isolated nucleic acids. The invention further includes nucleic acid and protein vaccines, and the use of the vaccines to immunize a subject against flavivirus infection. The invention also provides antigens encoded by the nucleic acids of the invention, antibodies elicited in response to the antigens, and the use of the antigens and / or antibodies in detecting flaviviruses or diagnosing flavivirus infections. |