| abstract |
A novel 5-substituted-2-arylpyridine compound is provided. Such compounds can act as selective modulators of the CRF receptor. The 5-substituted-2-arylpyridine compounds provided herein are useful in treating many CNS and peripheral diseases, particularly stress, anxiety, depression, cardiovascular disease, and eating disorders. Also provided are methods of treating such diseases, as well as packaged pharmaceutical compositions. The compounds provided are also useful as probes for CRF receptor localization, as standards in CRF receptor binding assays. Also shown is the use of the compounds in receptor localization studies. |