abstract |
A pharmaceutical analgesic composition comprising an opioid analgesic and a compound that binds to the SS1 or SS2 subunit of a sodium channel, such as tetrodotoxin, saxitoxin and analogs thereof. Administration of a drug analgesic composition comprising an opioid analgesic and a compound that binds to the SS1 or SS2 subunit of the sodium channel, such as tetrodotoxin, saxitoxin and its analogs, results in analgesia in the treatment of pain in mammals. |