| abstract |
The present invention provides a compound of formula (I) Embedded image Wherein R 1 -R 4 , Het, Z 1 , A, Ar, and m are as defined in claim 1 , Their tautomers, their stereoisomers, their mixtures, their prodrugs and their salts, which exhibit beneficial properties. A compound of formula (I) wherein R 4 represents a cyano group represents an intermediate product useful for preparing the remaining compounds of general formula (I), and R 4 represents an amidino group according to claim 1. The compounds of the above general formula (I), which represent one of the above, exhibit beneficial pharmacological properties, in particular antithrombotic and factor Xa inhibitory effects. |