abstract |
The present invention relates to oncolytic adenovirus vectors and their use in methods of gene therapy. A recombinant viral vector comprising an adenovirus nucleic acid backbone is provided. Here, the nucleic acid backbone in turn comprises: an ITR on the left, a termination signal sequence, an E2F responsive promoter operably linked to a gene essential for replication of the recombinant viral vector, an adenovirus packaging signal, And the right ITR. |