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filingDate 2001-10-12-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationDate 2004-09-30-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber JP-2004529610-A
titleOfInvention Human anti-epidermal growth factor receptor single chain antibody
abstract Using a purified epidermal growth factor receptor as an antigen, a human anti-epidermal growth factor receptor (EGFR) single chain antibody (scFv) was isolated from a human IgM phage display library. Isolates with two different amino acid sequences were identified as specific for the epidermal growth factor receptor by ELISA. These scFvs bind to the full-length epidermal growth factor receptor on human cells and to truncated and / or mutant epidermal growth factor receptors. These anti-EGFR scFvs are useful as therapeutic and / or diagnostic agents.
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