| abstract |
The present invention provides a compound of formula use as a vascular damaging agents (I) [wherein: X is, -O -, - S -, - S (O) -, - S (O 2) -, - N (R 4) — Or —N (R 4 ) CH 2 C (O) —; R 1 is amino, halo, hydroxy, —OPO 3 H 2 , C 1-4 alkyl, C 1-4 alkoxy, N— Independently selected from C 1-4 alkylamino, N, N-di-C 1-4 alkylamino, C 1-4 alkanoylamino, or C 1-4 alkylthio, wherein the amino group is an amino acid residue R 2 is selected from hydrogen or C 1-4 alkyl; R 3 is selected from hydrogen or C 1-4 alkyl; R 3 is selected from hydrogen or C 1-4 alkyl; 4 is selected from hydrogen or C 1-4 alkyl; n is 0, 1, or 2 And p is 0, 1, 2, or 3], or a salt, prodrug, or solvate thereof. The present invention also includes a method of making a compound of formula (I), its use as a medicament (including a method for the treatment of angiogenesis or a condition associated with angiogenesis), and a compound of formula (I). To a pharmaceutical composition. |