abstract |
The present invention relates to a new class of compounds of formula (I), which are inhibitors of caspases and TNF-α. The present invention also relates to pharmaceutical compositions containing these compounds. The compounds and pharmaceutical compositions of the present invention are particularly suitable for inhibiting the activity of caspases and TNF-α, and consequently advantageously, caspases, interleukin-1 (“IL-1”). Apoptosis, interferon-gamma-inducing factor (IGIF), interferon-gamma ("IFN-γ") or TNF-α-mediated diseases, including inflammatory diseases, autoimmune diseases, destructive bone disorders, proliferative disorders, infections Sexual diseases and degenerative diseases). The present invention also relates to a method for preparing a compound of the present invention. |