http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2004524323-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-245 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K51-088 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-57419 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K7-06 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K5-083 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K7-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K51-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-245 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-574 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K7-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K51-08 |
| filingDate | 2002-03-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2004-08-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-2004524323-A |
| titleOfInvention | Tetradentate peptide-chelate conjugate for colorectal cancer diagnosis |
| abstract | Disclosed are peptide-chelate conjugates having affinity for the ST receptor, wherein the chelate is tetradentate. A low molecular weight thermostable toxin is produced by the enterotoxin strain of E. coli. This toxin, known as the ST peptide, mediates acute diarrheal disease by binding to its receptor on colonic colon cells and stimulating guanylate cyclase. Gastrointestinal mucosal cells specifically express the ST receptor, and expression continues after colon and rectal mucosal cells have undergone malignant neoplastic transformation. The peptide-chelate conjugate of the present invention can be labeled with a radioactive metal to provide a metal complex. In a preferred embodiment, the radiometal is 99mtc, and the chelating agent is selected from diamine dioxime, diamine diphenol, N3S, N4, and N2S2 ligand. There is provided a radiopharmaceutical composition comprising the metal complex, which is suitable for diagnostic imaging of colorectal cancer. The present invention also provides a kit for preparing a radiopharmaceutical composition. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2017503763-A |
| priorityDate | 2001-03-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 166.