| abstract |
The invention includes a composition comprising a pharmaceutically acceptable carrier and an active agent complexed with glycyrrhizin, wherein the active agent comprises at least one nitrogen-containing moiety, wherein the composition comprises an unconjugated agent. Substantially free of embodied actives. Glycyrrhizin is preferably glycyrrhizic acid, more preferably 18-alpha- or 18-beta-glycyrrhizic acid. Glycyrrhizic acid is preferably ionically complexed with the active agent. The active agent can be famotidine, buspirone, sildenafil, caffeine, or loratadine. Preferably, the molar ratio of glycyrrhizic acid to activator is from 1: 1 to 1: 3. The nitrogen-containing moiety is preferably an acyclic or heterocyclic amine, amide, imine, imide, or nitrile. |