| abstract |
Formula (I) wherein X is> C = CH 2 or —CH 2 —; Y and Z are each independently hydrogen, fluorine, or hydroxy; A is —O (CH 2 ) 3 —, — (CH 2 ) 2 — (1,2-C 6 H 4 ) —, —CH ＝ CH— (1,2-C 6 H 4 ) —, —C≡C— (1,2-C 6 H 4) ) -, - (CH 2) 2 -CO -, - CH 2 -O-CO -, - CH 2 NHCO-, or -CH 2 NHCOCH 2 - a and; R 1 is an C 1 -C 5 alkyl; R 2 and R 3 independently of one another are alkyl or perfluoroalkyl; and R 4 is hydrogen, hydroxy, C 1 -C 5 alkyl, or C 1 -C 5 alkoxy]; psoriatic, basal cells Treating or treating hyperproliferative skin diseases such as cancer, keratosis disorders and keratosis; neoplastic diseases; sebaceous gland disorders such as acne and seborrheic dermatitis. Is the use of such compounds to prevent; oral or topical treatment of effects such as skin damaged by sun exposure, wrinkling, elastic fibrosis, and premature aging in the recovery of conditions associated with photodamage. The use of these compounds is disclosed, as well as methods of making such compounds, and pharmaceutical compositions containing such compounds. |