| abstract |
Provided are polynucleotides encoding at least one immunizing antigen whose expression is controlled by a promoter from the gene encoding the costimulatory molecule. The polynucleotide may also encode an adjuvant. Also provided is a composition comprising at least one immunizing agent and at least one cytokine, which enhances the stimulation and / or survival of dendritic cells. Methods for raising an immune response to an immunizing agent are also provided. The method includes the steps of administering a polynucleotide and, if necessary, co-administering an adjuvant. |