| abstract |
The present invention relates to oncolytic microorganisms expressing HSPs, compositions or pharmaceutical compositions containing them, and methods of killing local and metastatic tumors using them. The microorganism refers to a virus or a bacterium, which can selectively grow within tumor cells to lyse the tumor cells. While the microorganism or composition according to the present invention is administered to a tumor patient, the oncolytic microorganism lyses the tumor cells, and the heat shock protein expressed by or administered during the oncolytic microorganism, It attaches to tumor antigens released by the cells and binds to antigen presenting cells to induce a specific immune response against the tumor cells, then kills the metastatic tumor. |