| abstract |
Formula (I): Embedded image [Where, R 1 and R 3 are the same or different and = O, hydrogen, C 1-6 alkyl, C 1-6 dialkyl, CHCHC 1 -C 5 alkyl, SS, or 5 or 6 members Represents an aryl of R 4 -R 9 are the same or different and are hydrogen, C 1-6 alkoxy, OCF 3 , OCH 2 CF 3 , O-cyclopropyl, OCH 2 -cyclopropyl, C 1 -C 6 alkyl, Represents S-alkyl, NR 2 10 (R 10 is hydrogen or C 1-6 alkyl), halogen, NO 2 , OH, CH 2 OC 1 -C 6 alkyl, CH 2 OH, or CF 3 ; Q 1 is hydrogen, C 1-6 alkyl, C 1-6 dialkyl, C 1-6 alkoxy, NHAc, NR 2 10 (R 10 is hydrogen or C 1-6 alkyl), difluoro, fluoro, OO Or OH; Q 2 , Q 3 , Q 4 and Q 5 are the same or different and are hydrogen, C 1-6 alkoxy, OCF 3 , OCH 2 CF 3 , O-cyclopropyl, OCH 2 -cyclopropyl, C 1 -C 6 alkyl, S-alkyl, NR 2 10 (R 10 is hydrogen or C 1-6 alkyl), halogen, NO 2 , OH, CH 2 OC 1 -C 6 alkyl, CH 2 OH, or 5 Represents a 6-membered or 6-membered aryl; However, the compound [4- (1-oxo-1,3-dihydro-2H-benzo [f] isoindol-2-yl) phenyl] -2-propionic acid, sodium salt and [4- (4,9-diethoxy) Except for 1-oxo-1,3-dihydro-2H-benzo [f] isoindol-2-yl) phenyl] acetic acid And a pharmaceutically acceptable derivative thereof. |