| abstract |
The following structural formula: Embedded image Wherein R 2 is R 3 is 1) hydrogen, 2) halogen, 3) C 1-4 alkyl, 4) C 3-7 cycloalkyl, 5) CF 3 , 6) OCF 3 , 7) C 1-4 alkoxy and 8 R 12 has from 2 to 4 heteroatoms provided that at least one heteroatom is N and at most one of the heteroatoms is S, and is unsubstituted. A 5-membered heteroaryl ring wherein one or any one ring atom is replaced by CH 3 ] A compound of the invention having the formula: or a pharmaceutically acceptable salt thereof is useful for inhibiting thrombin and related thrombotic occlusions. |