| abstract |
The present invention relates to a new type of peptide nucleic acids with improved properties (PNAs). In particular, the present invention relates to positively charged PNA units having an ethylene linker between the backbone and the nucleobase, oligonucleotide analogs containing these units, oligomers containing these units, and antisense It relates to the use of positively charged PNAs as novel delivery agents, including therapeutic and diagnostic applications, including therapeutic uses. |