abstract |
Following formula: [Chemical 1] Wherein X, R 1 , R 2 , R 3 , R 4 , R 4a , R 5 , R 5a , R 6 , R 6a , R 7 and R 8 are the same as described in the specification, Sulfonamide lactams are disclosed. The compound is an inhibitor of Factor Xa and is useful as an anticoagulant in the treatment of cardiovascular diseases associated with thrombosis. |