| abstract |
The present invention relates to compounds of formula (I) below and their pharmaceutically acceptable salts useful for inhibiting cancer cells or sensitizing cancer cells to chemotherapeutic agents, radiation or other anti-cancer treatments. About: Embedded image Wherein R 1 is lower alkyl, lower alkenyl, (hydroxy) lower alkyl, lower alkynyl, phenyl, benzyl or 2-thienyl, and R 2 , R 3 , R 4 , and R 5 are the same or different And each R 6 is independently hydrogen, lower alkyl, hydroxy, (hydroxy) lower alkyl, lower alkoxy, benzyloxy, lower alkanoyloxy, nitro or halo; -3, R 7 is hydrogen, lower alkyl or lower alkenyl, X is oxy or thio, and Y is carbonyl (CH 2 ) 1-3 , (CH 2 ) 1-3 C (O ) Or (CH 2 ) 1-3 SO 2 , wherein Z is (ω- (4-pyridyl) (C 2 -C 4 alkoxy), (ω-((R 8 ) (R 9 ) Mino) (C 2 -C 4 alkoxy) wherein R 8 and R 9 together with H, (C 1 -C 3 ) alkyl or N together with 1-3N (R 8 ), S or non-peroxide O And (ω- (OH) (C 2 -C 4 )) alkoxy amino acid ester, N (R 8 ) CH (R 8 ) CO 2 H, 1′-D -Glucuronyloxy, wherein YZ is (CH 2 ) 1-3 R 8 [where R 8 is OH, (C 2 -C 4 ) acyloxy, SO 3 H, PO 4 H 2 , N (NO) (OH), SO 2 NH 2 , PO (OH) NH 2 or tetrazole]. |