http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2004518419-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-1062 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-1075 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-705 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-10 |
| filingDate | 2001-11-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2004-06-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-2004518419-A |
| titleOfInvention | Substrate-linked directional evolution (SLiDE) |
| abstract | The present invention relates to a method for the evolution of molecules having improved biological properties. In particular, the present invention relates to methods of using proteins that modify DNA substrates to establish a relationship between the action of these proteins and the selection of molecules with improved biological properties. A uniform feature of all these mechanisms is that the coding region to be evolved is in the same genetic element or on the same DNA molecule as the target site of the DNA modifying protein. Thus, the activity (or inactivity) of a DNA modifying protein can be tested by evaluating the sequence of its nucleic acid substrate. In this manner, a number of different types of compounds are selected, including improved DNA-modifying proteins, improved substrates for DNA-modifying proteins, improved ligand-receptor interactions, improved cofactors. And regulatory protein activity, improved DNA binding proteins and the like. |
| priorityDate | 2000-12-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 258.