| abstract |
The present invention relates to an antithrombinic compound of the general formula (I): (Wherein R 1 -R 4 , R 8 , R 9 and Ar are as defined in claim 1), and compound 2- (5-carbamimidyl-2-hydroxy-phenyl) -N- [3-chloro-4- (pyrrolidin-1-yl-carbonyl) -phenyl] -acetamide, its tautomers, stereoisomers, mixtures thereof, prodrugs and salts. The compounds of the above general formula (I), wherein Ar represents a phenyl or naphthyl group substituted by radicals R 5 , R 6 and R 7 , and R 5 represents a cyano group, correspond. compounds of general formula (I) (wherein, R 5 is optionally one or two C 1-3 -. representing the amidino group substituted by an alkyl group) intermediate product of value in order to generate It is. The compounds of the general formula (I) have valuable pharmacological properties, except that Ar represents a phenyl or naphthyl group substituted by radicals R 5 , R 6 and R 7 , and R 5 represents a cyano group. It has properties, especially antithrombin activity and factor Xa inhibitory activity. |