| abstract |
The present invention provides a method of treating a subject in need of treatment for osteoarthritis, said method comprising administering to said subject a dose of an inhibitor of spermidine biosynthesis that is sufficiently effective to substantially inhibit spermidine biosynthesis. Administering to the subject. The present invention also provides the use of an amount of an inhibitor of spermidine biosynthesis that is effective enough to substantially inhibit spermidine biosynthesis in treating a subject in need of treatment for osteoarthritis. The invention further provides a method of producing a therapeutic composition for treating a subject in need of treatment for osteoarthritis, and the invention further provides a method of identifying an inhibitor of spermidine biosynthesis, comprising: Provided is a method, wherein the inhibitor is a spermidine synthase inhibitor. |