| abstract |
The present invention relates to novel pyrazolopyridine derivatives of the formula (I) and salts, isomers and hydrates of the derivatives. In formula (I), R 1 is hydrogen or a di-C 1-6 -alkylaminocarbonyl group; R 2 is a group of formula —O—CO—NR 3 R 4 ; R 3 and R 4 Is the same or different and is selected from the group consisting of optionally substituted C 1-6 -alkyl, optionally substituted C 2-6 -alkenyl, or optionally substituted C 3-8 -cycloalkyl. Or together with the nitrogen atom to which they are attached, form a 5- to 7-membered saturated heterocycle, wherein said heterocycle is an additional member from the group of N, O, S Heteroatoms may be optionally included and / or optionally substituted. These derivatives are used as stimulants of soluble guanylate cyclase and as agents for treating cardiovascular diseases, hypertension, thromboembolic diseases and ischemia, sexual dysfunction, inflammation and central nervous system diseases . |