| abstract |
The present invention relates to compositions and crystals of CD154 (CD40L) complexed with an anti-CD154 antibody. Further, the invention relates to the high resolution structure of the CD154 / anti-CD154 antibody complex when obtained by X-ray crystallography. Specifically, the structure provides a binding site defined by the structure coordinates determined herein. The invention also relates to a computer (machine) comprising a machine-readable data storage medium. The data storage medium includes a data storage material encoded with machine readable data, including the structural coordinates provided by the present invention. The computer has instructions for processing the machine-readable data into a three-dimensional representation of the CD154 / anti-CD154 antibody molecular complex based on the structural coordinates provided by the present invention. |