| abstract |
The present invention relates to an α-virus-based expression vector that expresses the HIV-1 env, gag, pro, and pol genes, its RNA transcript, and transformed host cells. According to the present invention, the Gag, Env, Pol and / or Pro protein of HIV-1 is expressed using the expression vector, and HIV-like particles comprising the recombinant protein are produced. The virus-like particle of the present invention is preferably a mature, infectious virus particle, which can be used as an antigen of a diagnostic kit for diagnosing the presence or absence of HIV infection, and a vaccine composition for preventing HIV infection. Can be used usefully. |