abstract |
Novel compounds of the general formula 1 which antagonize the action of the glucagon hormone on the glucagon receptor; wherein Z is an arylene or a 5- or 6-membered member containing one or two heteroatoms selected from nitrogen, oxygen and sulfur Is a divalent group derived from a heteroaromatic ring. The compounds may, by virtue of their antagonism at the glucagon receptor, treat and / or treat any disease or disorder in which glucagon antagonism is useful, such as hyperglycemia, type 1 diabetes, type 2 diabetes, lipid metabolism disorders and obesity. Suitable for prevention. |